Episode 216 — CBD Quells Neuroinflammation
Guest: Dr. Chris Shade • Date: August 8, 2024
Episode Overview
We're talking CBD this week with Christopher Shade, PhD, founder and CEO of Quicksilver Scientific, a company known for its detoxification protocols and unique supplement delivery systems. Dr. Shade, an expert on mercury and liposomal delivery systems, discusses the role of CBD and cannabinoids for children on the spectrum.
About Dr. Chris Shade
Christopher Shade, PhD, founder and CEO of Quicksilver Scientific, continues to be the driving force of development and innovation. Dr. Shade’s vast depth and breadth of knowledge, passion for healing, and intuitive understanding of chemistry and biology are reflected in Quicksilver Scientific’s well-designed detoxification protocols, unique supplement delivery systems, and patented mercury speciation test. Dr. Shade is a recognized expert on mercury and liposomal delivery systems. He has lectured and trained doctors in the U.S. and internationally on the subject of mercury, heavy metals, and the human detoxification system. Dr. Shade's current focus is on the development of cutting-edge, lipid-based delivery systems for nutraceuticals, such as liposomes and micro-emulsion systems, to address the growing need for high-quality, affordable detoxification solutions.
You’ll Discover
The Key Driver of Constant Fight or Flight (5:04)
Something That Prevents Detoxification (9:09)
The Importance of CBD Delivery Systems (10:42)
The Blends of CBD To Consider (14:08)
What Exactly Is Neuroinflammation? (19:47)
Options That Calm and Detoxify (22:46)
Benefits You May See Quickly (33:10)
What Are Endotoxins And How To Avoid Them (32:20)
The Importance of Oral Hygiene (35:26)
Referenced in This Episode
Full Spectrum Bliss by Quicksilver Scientific (use code APS for a discount, note creating an account is needed to access this link)
Full Transcript
Dr. Chris Shade | 00:00
You're locked in sympathetic and sympathetic is fight or flight, right? And what's parasympathetic? People say rest and digest. It's rest, digest, repair, regenerate, detoxify. It's all the healing things. This is why CBD is so fundamentally profound, because it's allowing you to drop out of sympathetic into parasympathetic. And that on its own, even if it didn't do anything else, is going to allow you to heal.
Cass Arcuri | 00:28
Want to truly be the best parent you can be and help your child thrive after their autism diagnosis? This podcast is for all in parents like you who know more is possible for your child.
Len Arcuri | 00:39
With each episode, we reveal a secret that empowers you to be the parent your child needs now, saving you time, energy, and money, and helping you focus on what truly matters most, your.
Cass Arcuri | 00:49
Child. I'm Cass. And I'm Len. Welcome to Autism Parenting Secrets.
Len Arcuri | 01:06
Hello and welcome to Autism Parenting Secrets. It's Len, and joining me today is Dr. Christopher Shade. Founder and CEO of Quicksilver Scientific, and Dr. Shade is renowned for his expertise in mercury and liposomal delivery systems, and his company is known for its innovative detoxification protocols and supplement delivery methods. Today, we'll discuss how CBD and cannabinoids can benefit children on the spectrum. The secret this week is... CBD quells neuroinflammation. Welcome, Dr. Shade.
Dr. Chris Shade | 01:43
Thank you. Very happy to be here, Len.
Len Arcuri | 01:45
Well, I'm excited to have you because I've seen you talk many times going back, way back, probably a dozen years to early conferences in the autism space. And you've been out there with very unique and compelling ways of looking at what's going on with a child and what parents might be able to do to help.
So I'll hand it off to you to talk a little bit about kind of what is bringing you to do this work. In this space, not just for children on the spectrum, all people, but you seem to have a special affinity for kids who are on the spectrum.
Dr. Chris Shade | 02:19
Yeah, I... You know, it's always funny, you know, how do you get into what you do?
I mean, I was sort of a reductionist guy in college and, you know. Did a couple of things that freed my mind, let's say, and went from being an environmental chemist to being an organic farmer. And I wanted to save the world by, you know, changing the food supply and making better soil. And, yeah, Did that for a while, then got out of that and went back to school and got into... Looking at first agricultural pollution in the environment and organic farming.
And then in a switch, I went to mercury as a toxin and developed some technology during grad school for measuring different forms of mercury in the body. It was called mercury speciation. And, you know, at the time, people had a lot of dental amalgams and they're eating fish. We had to look at the different forms. And I thought I was just going to do that. And, you know, once you show a problem, you have to be able to fix it too. And I was taking some of the synthetic chelators that were out there, then DMSA, DMPS, and just really laid waste to my body. It just made me worse. And I realized that the way we were going about detoxification was completely wrong. And that there's a way to just amplify the way your body's doing it. And just, you know, that's really why we're toxic.
Yeah, we're exposed to a lot of stuff, but, you know, it's a little different. We're not in a totally industrial land. It's just, there's just so much of it now, but there's none of it is super acute. But then when our detox systems are turned down, then we're accumulating this soup of different toxins. And I saw if we could just turn it back up and get them working right, everything would start to come out.
So we started developing this system based on getting toxins from the cells to the blood, from the blood to the liver, coupling that movement with the bile and then picking them up with a binder in the GI. And I was like, wow, this really works. And I started working in autism. I started going to autism one conferences back, I don't know, 2013. And I saw, you know, they were very difficult to detox and very difficult to work with because whatever you gave them, they like lit them up and, you know, they would go.
Len Arcuri | 04:45
Well, these kids are super sensitive, right? Super.
Dr. Chris Shade | 04:48
Sensitive. And you're activating them in a way and creating inflammation that's blocking the whole detox at a cellular level and an autonomic level. I'm like, how do we open this up? And I was like, Is this neurological or immunological?
You know, so then enter in CBD. It comes onto the landscape. We get into it right away and we my God, it just blew me away. Its ability to come and calm the whole system down. And, you know, fast forward a little bit of time and get a little time in the saddle with that. And I find that it's both immunological and neurological.
So neuroinflammation, which we'll talk about a lot today, is the key thing that's driving autism in the brain and driving this constant fight or flight and this constant anxiety and the stimming and that glutamate excess there. But the immune system is hyperactive too. And it turns out There's cannabinoid receptors in the brain, we know, but they're on the immune cells.
So the mast cells and macrophages that get like too angry, you can calm them down with CBD too. And so we found that if we brought this nano CBD, and we'll talk about our delivery system, to bear on the situation, it calmed down the child and gave you this opening where you can go in and do your detoxification.
So coupling the CBD, to this method of detox we had was just revolutionary. I just opened it up so we could really do advanced detox in these kids.
And then that extends into the Lyme and mold world, you know, even mercury, wherever people are, you know, neuro-inflamed, that is opening things up for successful detox because that inflammation is blocking detox. And so we have to open that up.
Len Arcuri | 06:42
Got it. Yeah. And I'm trying to track with everything you're saying. And I'm wondering, what's the sequence here? Is it that detoxification is really important, but you can't detox if your body's kind of in this hyper aroused state? Or it's the opposite.
Dr. Chris Shade | 07:00
You know, it's a little of both, you know, it's a chicken and the egg thing because the toxins wind up the glutamate receptors in the brain, which makes you all like, and you know, so the toxins themselves are blocking detox. And so, Really, we end up sequencing these things right next to each other.
You know, take your CBD and, you know, if you can wait five minutes before the next one, that'll give you a little advanced. If you can't just get it in, you get the CBD in there and we use these. Nano deliveries, liposomes and nano emulsions that we can measure in the blood in two minutes. In five minutes, you're feeling it. In 20 minutes, it's peaking.
So that come down from the CBD happens really quick. It's not like a capsule that takes two hours.
So that come down happens really quick. And then we can put in all the detox stuff and come in with the binders half hour later.
So you're just addressing it all at the same time. Sometimes if they're real anxious, you might start for a week on just the CBD, just calming down the system. But because these deliveries are so quick, you can stage this stuff like CBD, liver, binder, like really quick behind one another and just get the whole system to come down.
And then the farther you get, the less toxins are aggravating the nervous system, the more nervous system is agonizing. Calming down and getting entrained into a more gentle space internally.
Len Arcuri | 08:27
Got it. Yeah, no, and I think that's the unique nature of what your company provides, right? It's like a system, an approach for doing this in a much more effective way. And again, for parents or people who are listening, you know, the concept that I think anyone listening understands neuroinflammation is an issue and that detoxification is likely at least a kind of reason why your child may be stuck and in a certain state.
So I think it's just powerful for people to understand that from your perspective, you're saying, detox really can't happen. That inflammation is blocking that from happening as it's naturally designed to happen.
Dr. Chris Shade | 09:08
Yeah, exactly. Inflammation blocks detox. They're like this. And so if you can't quell that, you can't get this stuff out. And even this is just like sort of pulling the bar down and throwing the toxins over the top.
And then, you know, you get a window to do that. Then it you know, raises back up and then you do it again, pull the bar down, toss the things over. And the more you do that, the more the bar, you know, of inflammation is coming down and you're getting a whole system.
Len Arcuri | 09:37
Yeah, so that makes sense to me. And when I think about CBD, which we haven't really, with our son, he's 17 now, we never really went down this road, although I would go to conferences every year. And I remember one year, Autism One was in Colorado Springs. And the year before, there was really no CBD vendors.
And then that year, it was like half CBD vendors. And so when parents are looking, it's a little bit confusing now because you can buy it anywhere, right? Any grocery store.
So talk a little bit, if you could, about the importance of the delivery method and even the types, whether it's CBD or whether it includes THC or not. Can you talk a little bit from your perspective?
Dr. Chris Shade | 10:15
Yeah, so there's a couple of things. We'll talk delivery system first, and then we'll talk about... Full spectrum, broad spectrum, other things blended in.
So CBD has a low absorption. You know, it's like, Summer you know, six to 10% absorbed and the rest just passes right through and it's very slow in its absorption. It's absorbing over hours. And so if you're trying, if you're like in this hyper aroused state and anxious and you're trying to use it to calm down, it's like two hours till it does anything. And, Then... You have to take a lot to get enough of a blood level.
And then that last thing, once it gets, takes a long time to get in, long time to get out, And it's really variable. Like one day you're absorbing a lot, one day you're not. One kid absorbs a lot, one kid doesn't. When we did a pharmacokinetic study, that means you get a bunch of people, you dose them all up. After you dose them, you measure the levels of CBD in their blood for a couple hours and you'll see it go up and then come down.
And then you have a variation like, you know, at two hours, this guy's here, that guy's there. And you get to see this profile of how long it takes to come in and then go out and how variable it is. And when we did just CBD and oil in capsules, there was over 100% variation.
So from one of the 10 people being fairly high, one of the people not registering at all, really broad. So you really don't know, is he not responding to the CBD? Is that because he's not a responder or because he's not absorbing any of it? People's GIs are so bad now, absorption is so variable. That you can't predict. But then when we did the same group of people with the nano emulsion, it was about a 20, 25% variation, 30% of the most.
So everybody who took it, and it was all the same people who took the first kind, They're all in a certain window. So now we know if you take this and you do what we said, you know, hold it, swallow it, you're going to be in a certain blood range. And so we know it's in there.
And then if you don't respond or you need more, then we know for sure. But most people respond. And so The peak... To full activity is only like 20, 15 to 25 minutes, depending upon the person.
So if you're hyper aroused, you know it's gonna calm down real quickly. In fact, you can give it to the kids and you can just see them melt down right in front of you. And it seems to be able to get across the blood brain barrier more. This is a hard thing to measure because obviously we're not gonna drill into your brain and measure the CBD concentrations in there. But you're able to see Even at smaller doses, more of a neurological effect. And theoretically, these kind of particles, these particle size, the types, they're supposed to be able to get across the blood brain barrier earlier, easier.
So you get more of a penetration of the cannabinoids into the brain to do everything. So you get immediacy, you get six times more in the blood and you get more activity on the brain. And so even just using CBD outside of detox and people dosing usually twice a day, really see a change in the whole tenor of the body. It's much more, you're much more comfortable in your skin. The children are that, High tone is calming down. The stimming is calming down.
So especially for those toned up kids, it's just a miracle. Just a really great product, even no matter how you get it in. But getting it in this way, all the parents would be like, I'm getting so much more change getting it in this way than otherwise. Now, Blends of CBD, broad spectrum, full spectrum. Those are the first two things that you're going to see. Broad spectrum, means You don't have any THC. And full spectrum means all the cannabinoids, including the legal amount of THC. Are in there. And generally this is 25 to 50 parts CBD to one part THC. I like between 25 and 30 parts CBD to one part THC for a little bit of that THC action. The THC action is that it is a very strong agonist for the cannabinoid receptors.
So this gets into how does CBD work in the body? They talk about increasing the endocannabinoid tone.
So the reason you smoke a joint and get high is because you have THC receptors, you have cannabinoid receptors in your central nervous system and in the peripheral system that's highly associated with the immune system. And these cannabinoid receptors were put there or evolved there for your endocannabinoids, your inner cannabinoids. The main one in the nervous system is called anandamide. Ananda is the Sanskrit word for bliss, and it's known as the bliss molecule, and it's associated with meditators high or runners high. They used to think that those were...
You know, endo, what do they call them? They're sort of opioids. I forget what they called those. But endorphins. But they found endorphins thrown across the blood-brain barrier. It's actually anandamide being made, and it's an omega-6 fatty acid derivative.
And then there's one called 2-arachidonylglycerol that is Some in the immune, but heavily in the peripheral system and involves a lot of immune signaling. In fact, your biggest, you know, the first time you get high on a big dose of cannabinoids is the first time you breastfeed. Because mother's milk, especially when you're born, has a whopping amount of 2-arachnidol glycerol, and it's helping the immune system start to train itself into us versus them. And so it's really fundamental. In fact, it's so fundamental that... The highest density of cannabinoid receptors is actually in the female uterus where it's interacting with estrogen to prepare the lining of the uterus for implantation.
So this is really core to our evolution, and it's involved in the central nervous system and the anandamide with award and behaviors and desire for food and satiation. It's all this stuff that it does. And so you make these intercannabinoids and they're supposed to be creating this sort of peace and harmony in the system. And they work on, I call neuroendoimmune. They work on neurological level, hormonal level, and an immune level. And remember on the immune cells, there's cannabinoid receptors. And if you hear Judy Mikevitz talk about it, she'll talk about cannabinoids dimming down the immune cells, just dimming down that hyperactivity. And, you know, I mean, on like an extreme, like if some kid has to have some vaccine, Yeah, you know, she'll talk about, well, load him up with cannabinoids so he doesn't hyperreact to it. And so there's a lot of ways where it's creating harmony in the system, especially that nervous system harmony with the immune and the hormone system.
So, you know, I can't stress enough how fundamental the endocannabinoid system is. So You think, okay, CBD goes and hits the CBD, the CB, the cannabinoid receptors. No, not really. There's cannabinoid receptor one in the central nervous system and two is some in the central and heavily in the peripheral. CBD doesn't really have a punch on those, but what it does is... Helps the body make more of the endocannabinoids.
So it makes you synthesize more arachidol and glycerol, and it helps you, kind of like an SSRI, prevents the breakdown of the anandamides and pools up the anandamide. And as you're going with that, your body gets used to making more and more of the endocannabinoids and have more of the signaling going. At the same time, it seems to make the receptors more receptive to other cannabinoids like THC.
So THC has a very strong affinity for both CB1 and CB2 receptors. So a little bit of THC in there really greases the system and turns it on. One of the things we just did, we're the first that I've seen in any of the major companies that make CBD to do this, is to get anandamide, pure anandamide, synthesized from the raw fatty acids that it's made from. And put it in the product. And so we have a full spectrum with anandamide that is just so good. In fact, it's so good, you usually use about half of what we used to use. We used to do four pumps twice a day. Now it's like two pumps twice a day with these kids. And it's really good with the anandamide in there. It really gets that whole system running and calming everything down. Then you can do other things you can add. It's so, When you go to talk about neuroactivation or neuroinflammation, first just take a little side lesson. What's neuroinflammation? That we'll come back to the products for. Neuroinflammation is where something triggers the immune system in the brain which is supposed to be a pacified immune system. Your microglia in the brain are supposed to be involved with synaptic pruning and plasticity and rewiring the brain and keeping it cleaned up, even cleaning up things like plaques. But then certain things trigger from the outside to become more like the peripheral immune system and release pro-inflammatory cytokines, like it's trying to fight a war in the brain. And those pro-inflammatory cytokines and reactive oxygen species are going and they're irritating the neurons at the glutamate receptors.
And then the glutamate receptors start hyperfiring. If you remember glutamate excitotoxicity and the problems with taking MSG, when the glutamate receptors start going too hard, you get hypervigilant. And like a little bit of glutamate is great because it makes you vigilant and it creates memory and you're on it and you know what to avoid and what's good, you know, and what's danger, what's safe. But when that fires too much, your danger signals are firing too much. What do you have then? You have anxiety and fear and that. Hyperactivities coming from the glutamate receptors. Now they've been activated by the microglia and now they start releasing other compounds that reactivate the microglia.
So the thing's just like spinning like this, hot activated microglia, hot NMDA receptors, which are glutamate receptors, and the whole thing's just humming. And you have to calm it down. And you can calm it down both by calming down the macrophages and returning them back to their peaceful state, or by and or hopefully both by calming down the excessively triggered glutamate receptor. For instance, even a lot of toxins will activate the glutamate receptors. And so.
It's usually immunological, but even some things are toxins that do that. And endotoxin from leaky gut does that. Or you can activate the glutamate receptors. Either way, this thing starts going. We're usually doing both at the same time. There's toxins and endotoxin in there. This whole thing's going and it's like. And Yeah.
Len Arcuri | 22:25
Everything you're describing is basically a sympathetic state, correct?
Dr. Chris Shade | 22:28
Then you're locked in sympathetic and sympathetic is fight or flight, right? And what's parasympathetic? People say rest and digest. It's rest, digest, repair, regenerate, detoxify. It's all the healing things. This is why CBD is so fundamentally profound, because it's allowing you to drop out of sympathetic into parasympathetic. And that on its own, even if it didn't do anything else, is going to allow you to heal. Then on top of that, CBD has, it has NF-kappa B blocking. Those are fundamental triggers of inflammation. It can turn those down. NRF2 upregulating. These are fundamental detoxification triggers in your body. It turns those up. And so it's bringing so many things to bear on the situation.
So, we can calm down neuroinflammation with CBD by calming the microglia and calming the glutamate receptors. But what's the opposite of glutamate? The GABA receptors. GABA is the calm, is the parasympathetic. We can use GABA or things that activate GABA Herbs like skullcap activate GABA, passion fruit activate GABA receptors. In the hormones, if you're treating women, progesterone activates the GABA receptors.
So now there's more than one thing we can use together. And even other anti-inflammatories like curcumin, basal, all these things can go together.
So we have our We have a broad spectrum CBD if you're afraid of all THC and anandamides, just pure CBD. Then there's the full spectrum. With the anandamide, then we have something called CBD Synergies AX, kind of short for anxiety. And that has GABA. CBD, skullcap, and anandamide and another, cannabinoid called CBG. All that coming down to calm the system down. Yeah, it has some 5-HTP.
So that is a broad use. You know, people talk about the entourage effect is having all the different compounds from the plant. But I like to use all the compounds from the plant world to do what we want to do.
Len Arcuri | 24:47
Is there a particular formulation that you would suggest for parents who have a very sensitive, more very like. Fight or flight type experience with their child. And one, going back to what you started with, like they don't want to make things worse.
Dr. Chris Shade | 25:03
No, they don't want to make things worse, but when they have very strong fight or flight, you tend to have to go for stronger ones, but then you got to play around a little bit. All right.
So we got the CBD, the full spectrum bliss, pure CBD. Strong. The CBD AX, No THC in that one. But. Anandamide, a bunch of other herbs and the GABA. Often I will use that during the day and the Bliss at night because it will help you sleep a little bit more.
And then we have another one called LipoCalm, which has no CBD. It's GABA, skullcap. Passionflower and chamomile. That's very strong for bringing down a very activated person. Most people only use it at night because it's a very good sleep aid.
So if you're worried about cannabinoids totally, you've got Lipo-Calm and or GABA L-theanine. If you're just worried about THC for some reason, you know, some psychosis or something. And in general, the more extreme the autism, the more THC needs to come into the picture in general.
Some, because it's broad spectrum, don't do well with that. So then you have the AX, which has a bunch of different herbs and the GABA and the anandamide, but no THC.
And then you've got that full spectrum bliss with the THC and the bliss. There's one more that's a sleep one. Which is full spectrum. Melatonin 5-HTP. And the GABA and the herbals.
Len Arcuri | 26:43
Got it. Yeah, we'll include links where people can go and see. And as you were saying, it's a little bit complex and it might be some trial and error. Would a parent, if they're listening to this and excited to explore this opportunity, do parents usually just buy, purchase directly or are they usually working with like a MAPS or a functional medicine practitioner?
I mean.
Dr. Chris Shade | 27:04
I... I love parents to do everything. Directly have a practitioner, but not be so You've got to get empowered. You're the one who knows a kid more than any doctor does. You have to be the one to be the best treater. And that's, I've worked a lot with parents over the years back when I used to consult more. And, you know, they really get in a good groove of knowing exactly how the kid is with different things and, this works real well. And when I give them this, that works. And so I want them to figure it out as much as they can, especially if they have a little time at the saddle. And I know I give a lot of options there, but I would, you know, unless you're, unless you've got a problem with the THC, I'd start with just the full spectrum bliss, two pumps twice a day and work up from there. And then, but now what all those tools are, maybe get a couple of them and try them out different times of the day. I guarantee you're going to get results with this.
Len Arcuri | 28:05
That's great. And then you mentioned two pumps a day.
So in terms of the delivery, is it something that a child would be drinking or, cause I know there's.
Dr. Chris Shade | 28:13
All. So these, I was looking for a bottle here around me. They're in these pump bottles that go inside the mouth. And this is a problem sometimes with the autistic kids, but we just, this full spectrum bliss, we totally reflavored. If they can hold it in their mouth for 15, 30 seconds and then swallow, great. If that's just too weird for them, put it in a little bit of water or apple juice. And just have them take it straight down. If you, if there's, No food on board, great, empty stomach. Better, holding the mouth better, but just get it into them. And those two pumps start with that. The more extreme they are, the more intense it is, the higher the dose you got to go to and just find the dose that's really working well for.
Len Arcuri | 29:03
You. Okay. And so that whole process of the pumps, that's the liposomal delivery that you mentioned. Now, I think I lied to you because I know we did go down the CBD route ourselves with our son, where there was a company that made a product that was a cream that you applied directly to the brainstem. And I have to say, we weren't sure. It seemed like it might be helping, but otherwise, from your perspective, you're feeling like this liposomal way of delivering it is much more fast acting than.
Dr. Chris Shade | 29:32
Yeah, I mean, we've done uptake studies, you know, and on, we've done a ton of them, but Yeah, and I think the shortest time period we did in these was five minutes... In our first study, the first Time point was 25 minutes and it was already peaked in the blood. And it took two hours for the regular stuff to be. And, you know, it was like six fold higher.
I mean, it gets in and it moves the needle quick. You won't be. Wondering if this is doing something. It'll do something.
Len Arcuri | 30:08
Right. And that in and of itself is appealing.
So I know there's a lot of interventions parents do, and it may take a long time for them to see any kind of benefit. Yeah.
Dr. Chris Shade | 30:15
You're going to see two kinds of benefit. You're going to see the immediate, just look for their neurology, you know, and if you don't see some sort of softening of it, Go do a higher dose and it'll be some, it'll just come down for you. But that's nice. And realize then that's giving you an opportunity to do any other therapy. If it's a lifestyle or some other supplement, now you want to do detox. That parasympathetic opening there is your gateway to walk through into whatever therapy that you want to do after that or not. Just let them be in that state. But then you have longer term as the body sits, calms down more, it's going to start offloading and detoxing. All this stuff is going to get more ingrained into being into a calm state. And you can, these, you know, that peak is going to last, you know, three, four hours.
You know, it'll be like six hours till it's all the way down. And if you want, you can dose it three times a day and that's going to give you real good coverage.
You know, it just comes down to what you're trying to.
Len Arcuri | 31:21
Achieve. That makes sense. I know as you're talking, I'm thinking, you know, pretty much anything that my wife Cass and I did for our son, we would always try for ourself, right? It's a And I think everything you're describing, I mean, I know... I was in fight or flight and most of the parents we coached are all, you know, all could benefit from having less fight or flight in their life.
Dr. Chris Shade | 31:44
Definitely. I mean, I can't tell you how many moms would come up to the booth and I'd dust them right away and I'd make their protocol. They're like, what's the protocol for my son? I'm like, here's your protocol.
And then here's.
Len Arcuri | 31:56
Theirs. Super. No, it's an exciting area of opportunity. And again, here, I know the other caution I know parents have is, okay, well, they don't want to do anything that's going to make things worse. But from your standpoint here, there may be some trial and error, but there's no real downside that you've seen with kids in exploring this route?
Dr. Chris Shade | 32:17
No. I mean, you'll see some will have a paradoxical effect and they'll get little amped up instead of calmed down.
You know, What? So they're already up here. They go up a little bit and then you might determine, this one doesn't work. And, you know, the GABA, the GABA does work because, you know, some allergy it's usually. But it's not like, my God, now we're in trouble. It's just like, well, that's just for 10 percent of them. It's, you know, something else happens and it's like, well, that didn't work. Let's go a different route.
Len Arcuri | 32:51
Yeah. And for any parents who are going down this road, I think you touched on a lot of the potential.
Causes, like what might be at the root that's causing this state of chronic inflammation? So it's toxins generally, right? All kinds. You mentioned mercury. And can you talk a little bit more about if a parent's trying to play better defense and to fend off against toxins, what are some obvious things.
Dr. Chris Shade | 33:15
That they can do? Endotoxins and environmental toxins. Now, endotoxin sounds like a lot of different toxins inside because endo's inside. But it's mostly these are parts of bacteria that are getting into circulation from leaky gut. And so there's the whole GI driven toxicity, you know, A lot of these kids, especially the ones who will just eat crackers all day, they got wicked dysbiosis and you got nasty bacteria in there. You got bacterial toxins, you got the parts of the toxins, you got the leaky gut.
So the more you can do to Seal the barrier of the GI, the less you're having this flamethrower up there that's driving the inflammation everywhere and turning down detoxification. Then the toxins are coming in through the food. The air in the house, maybe you've got mold inside.
You know, it depends. The diet can go all over the place from totally toxic to a very well curated diet. And I know it's difficult with autism because they're so picky, but really being aware of the toxins that are coming from the food, being aware of the toxins that are in the house, being aware of your cleaning products.
You know, I mean, autistic kids are messy, but if you're using formula 409, just like you're going to have an issue. I mean, I totally like a good cleaner when you've got to get down to the shine, especially a bleach cleaner. But if you use it all the time, it's all over the air, it's all on the surfaces. And so you got to have non-toxic daily cleaners. Be aware of ventilation of housing... Be aware of anything you use on their skin, the soaps and creams.
You know, you've got to be living organic as much as possible.
Len Arcuri | 35:10
Yeah, no, all that matters. We've done many episodes covering all those topics.
So great reminder for parents. I know I've heard you mention about the another potential cause being, you know, kind of periodontal issues that kids may be experiencing. Okay, that makes sense. No, thank you. I think we've covered a lot of ground in terms of a lot of these potential stressors that may be contributing to this inflammatory state. I really appreciate you painting the picture on how to use CBD and particularly your kind of unique products and a way of delivering this that I know, again, to a person, everyone is wrestling with their child being in this hyper or over-agitated state. At least at times, if not throughout the entire day.
So I love that we've shown them a little bit more about why CBD and cannabinoids can actually help. And I know I found this extremely informative.
Dr. Chris Shade | 36:06
Yep, you got to try it.
Len Arcuri | 36:08
All right. Well, Dr. Shade, thank you so much for this discussion and again for all your presentations and all the ways that you've been serving parents for so many years.
So thanks so much.
Dr. Chris Shade | 36:20
Thank you, Len.
Cass Arcuri | 36:22
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