Episode 237 — Sequence The WHOLE Genome
Guest: Dr. Richard Boles • Date: January 2, 2025
Episode Overview
This week, Dr. Richard Boles, a renowned expert in pediatrics and genetics, explains the critical role of whole genome sequencing in creating effective, personalized treatments for autism, ADHD, and epilepsy. He also shares insights on genetic diagnostics, targeted therapies, and the supplements he developed to support mitochondrial function and neurotransmission.
About Dr. Richard Boles
Dr. Boles is a Medical Geneticist with expertise in mitochondrial disease, other metabolic disorders, and channelopathies. He completed medical school at UCLA, a pediatric residency at Harbor-UCLA, and a genetics fellowship at Yale. Dr. Boles’ clinical and research focus has been on the genetics of common, chronic neurological and functional disorders, including autism, ADHD, ME/CFS, pain, and cyclic vomiting. He has about 100 peer-reviewed published papers. After 20 years as a geneticist at Children’s Hospital Los Angeles and faculty at USC, Dr. Boles was the Medical Director of a DNA sequencing laboratory for 6 years. He is currently in a virtual (Zoom) private practice, where he applies whole genome (DNA) sequencing to determine the cause of disease in his patients. Dr. Boles is also the Chief Medical & Scientific Officer of NeuroNeeds, a company that produces natural nutritional products to assist people with neurological conditions, including the conditions listed above.
You’ll Discover
How Whole Genome Sequencing Works (5:41)
Why Telehealth Can Be Better Than In-Person Visits (8:37)
The Importance of Mitochondrial Function (19:45)
Who You Want To Focus on Pathways (24:57)
Specific Supplement Options (27:43)
Why De Novo Mutations Are Incredibly Important Clues (34:25)
Referenced in This Episode
Full Transcript
